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KMID : 1033920090060010001
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Journal of The Korean Academy of Geriatric Denstry
2009 Volume.6 No. 1 p.1 ~ p.5
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Bisphosphonates - their Chemical Structures and Action Mechanisms
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Lee Hyeon-Woo
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Abstract
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Bisphosphonates (BPs), pyrophosphate analogues, have been widely prescribed as agents against osteoclast-induced bone loss, Paget’s disease, bone malignancies, multiple myeloma, and hyercalcemia of malignancy. Selective action on bone is based on physical association of BPs moiety to the bone mineral. Recently, clinical uses of N-BPs (nitrogen-containing BPs) have been reported to be linked with several pathogenic conditions such as osteonecrosis of the low jaw. This may trigger to need the thorough examination of current uses of BPs therapy. Here, we review current understanding of the molecular action mechanisms of BPs and their chemical structures.
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KEYWORD
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Bisophosphonates, Osteoclasts, Action mechanisms
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